Saturday, November 14, 2015

Epigenetics and Primal Therapy: The Cure for Neurosis (Part 10/20)


How Traumas Get Embedded

A recent report from Northwestern University notes that some traumatic memories, such as chronic child abuse, are so painful that they get buried deep in the brain and become difficult to access (Jovasevic et al., 2015). Those memories were created in a certain mood/feeling or state of arousal and “can best be retrieved when the brain is back in that state.” This new brain research provides support for my concept of resonance, which posits that specific feelings on all three levels are inter-connected via related frequencies. In Primal Therapy, as the patient goes back in time in his sessions, he will connect with feelings stored deeper in the brain which resonate with the same mood, as one level of the memory is linked to lower levels. The mood or feeling belongs to a hierarchy of imprints/feelings, where each level gives way to deeper more remote levels, all related in tone and emotional meaning. The links are not only due to similar feelings but reflect historical processes; each link carries us further back in our ontology until we surpass memory as we think of it. We go back in archaic times as well, where there are no words or even feelings, just instincts. For that reason, when a patient uses words while appearing to relive such archaic events, we know it is abreaction, a false memory. When a patient is back in an accent brain, there are no words in the reliving because no words exist at that level. Let me be clear: the reliving is literal, as the patient is submerged in history and lives for a time on that lower level only.

In the Northwestern experiment, scientists infused the hippocampus of mice with gaboxadol, a drug that stimulates extra-synaptic GABA receptors. Researchers describe as getting the subjects “a little inebriated.” Then the mice were put in a box and given a brief, mild electric shock. When the mice were returned to the same box the next day, they showed no signs of fear and moved about freely, leading researchers to conclude they didn’t remember the shock from the day before. However, when the mice were given the same drug before going back to the box, they froze, as if fearfully anticipating another shock.

Researchers concluded that the drug changed the way the memory was originally encoded, so the mice remembered the stressful experience of the shock only when they were returned to the same brain state created by the drug. In other words, they believe that the brain, when drugged, “used completely different molecular pathways and neuronal circuits to store the memory.” And then the authors make this Primal statement: “The best way to access these memories is to return the brain to the same state.” Seems like a quote from my work, but it is no more than arriving at the same reality by different methods. The question is, how do we get the patient back in that state?

I repeat, the means of getting to those old memories needs to follow evolution; that is devolution or evolution-in-reverse. We need to begin at the last or latest link of memory and then use resonance to travel back in time to where key imprints lie. We don’t decide this; it is done by the patient who is often upset by something in the present, and once locked-in will slide effortlessly back in history following the feeling links. His devolution is not random; it is guided ineluctably by resonance.

So is Primal Therapy nothing more than a time machine, a means to revisit our history, to turn back the clock to previously neutral, non-neurotic states? It may sound far-fetched, but more and more evidence suggests it’s true. Scientists are now learning how to wind back the developmental clock on the microscopic level — taking a current skin cell, for example, and treating it so that it returns to a previously neutral, uncommitted state, an embryonic state. Once that is done, the cell can be reprogrammed to become another kind of cell. During this critical window certain needs must be fulfilled and, if they are not, cells may become imprinted in adverse ways.

Here’s another way to put it: once a mark is made on the cell we are psychologically and physiologically affected for life, until, and only until, the inciting event is revisited and relived. And it can be relived unconsciously, through the process of resonance. That is, a trauma that took place in-utero can be re-experienced without a specific awareness of it, by virtue of being part of the chain of pain, once we are locked into the memory circuit. In Primal Therapy, when we explore these ramified events and begin to relive them, we are connecting three levels of consciousness – the present, our past childhood and our infancy/gestation – by descending through three levels of brain development.

10 comments:

  1. A 2015 French rodent study “Integration of New Information with Active Memory Accounts for Retrograde Amnesia: A Challenge to the Consolidation/Reconsolidation Hypothesis?” expanded my understanding of the Northwestern study.

    The French researchers showed that any drug that causes an "internal state change," even if it’s just nausea, can trigger state-dependent memory.

    As both studies may apply to humans, a drug wouldn’t necessarily be required to "induce an internal state." An emotional or physical experience may be sufficient to produce a state-dependent memory.

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    1. You need to explain more. thanks for the interest and help. art

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    2. The French study found:

      “Memories can be established and maintained without de novo protein synthesis and that experimental amnesia may not result from a disruption of memory consolidation/reconsolidation.
      Posttraining/postreactivation treatments induce an internal state, which becomes encoded with the memory, and should be present at the time of testing to ensure a successful retrieval.
      This integration concept includes most of the previous explanations of memory recovery after retrograde amnesia and critically challenges the traditional memory consolidation/reconsolidation hypothesis, providing a more dynamic and flexible view of memory.”

      From an analysis of the study:

      “A different drug, lithium chloride, produces the same pattern of effects – it blocks ‘reconsolidation’, but this can be reversed by a second dose at the time of recall. However, lithium chloride is not an amnestic [a drug that blocks memory formation] – it doesn’t block protein synthesis. Rather, it causes nausea.
      The implication of the lithium experiment is that any drug that causes an ‘internal state change’, even if it’s just nausea, can trigger state-dependent memory and behave just like an ‘amnestic’.”

      As this study may apply to humans, a drug wouldn’t necessarily be required to “induce an internal state.” An emotional or physical experience may be sufficient to produce a state-dependent memory, in my opinion. For example, the Northwestern study found, albeit with rodents and use of a drug:

      “Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar.”

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  2. Dear Art

    My mind is occupied by one thing, that if you will die no one can save me and it will be to late. Yes I know this that it is my "magical" thinking but anyway it is all the time with me.

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  3. An email comment: "Awesome and clear, just wonderful. Yet, for those of us who cannot afford a move let alone your therapy it is small consolation except for some hope for a better future for others and perhaps for our world."

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  4. Another email comment: "Thank you very much for this BLOG! Since my computer was down, I am only now able to catch up on reading all of the emails. Although I faithfully follow the ones on epigenetics and believe the science behind our evolutionary system, I cringe at the idea of mice and rats as guinea pigs. (Not that I love these creatures, but inflicting pain for our sorry Human Conditions...?) When I majored in psychology years ago, I refused to work in an animal lab. Instead, I was allowed to take a computer-based Memory Lab course.

    What you are saying in this blog reiterates what Alice Miller said in her books. Regardless of what you believe about "self-therapy," after my first flashback on July 26, 1987, I have been on my own. My Freudian psychiatrist believed that repression should remain repressed. I slowly began to see how he had been harming instead of helping me. To one of my devastating emerging memories he responded with, "There's no evidence!! Had I not noticed how seductive toddler girls are?" I could have strangled him with glee! It took a while to gain enough courage to take on the journey on my own, the only support being Stettbacher's and Miller's books.

    How well I understand the rage! I felt like killing the whole world! Whenever possible, I locked myself in my bathroom and screamed for hours.

    Again many thanks."

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  5. Hi,

    slightly off topic. I've been experimenting, opening up the Primal Theory debate. . . or rather finding out that it is nearly entirely a 'closed subject'. There seems to be a very 'real' un-reality installed into people's psyche which prevents them from perceiving the terrifying truth of our collective (and individual) condition & therefore existence. Most of all with all this 'terrorism' there seems to be a complete 'herd mentality' of avoidance and belief. An almost romantic projection onto all the players in the game. The terrorists, their manipulators (who-ever they are), the police and most of all of course the victims. The media respond with increasingly predictable sound bites and wrap up the whole business with "have a nice day".

    The degree to which individual trauma & repression holds down genuine intelligence and the ability to truly respond seems to have no end, no bounds and no solution; hence we romanticise the whole situation and build altars of tragedy and well meaning epitaphs. One of the signatures of all this is that no sooner have we laid our wreaths at the feet of all this suffering do we hurriedly turn and depart back to the bustle of our own hectic lives. . . All "Out There".

    I am not cured and so have no 'proof' nor do I have 'evidence'. . . But something that I've learned has completely changed me, my outlook, and I wish with all my heart and all my natural intelligence that this 'knowing' could some how be imparted to others. Why? Surely not just because I want them to believe what I believe? No.

    Currently a particularly sane politician in UK has become ostracised because he refuses to engage in the politics of revenge. He will continue to refuse until what? Until he becomes the victim of a terror attack himself? Very likely because that is what Primal Pain does. Primal Pain allows almost any one to take OFFENSE and then to make OFFENSE the standard response to any conflict. This in turn becomes the rational for all further political dealings. Offense.

    On the radio right now the whole debate is reduced to one of violent retaliation and aggressive revenge. The public (allegedly) want RESULTS. . . but do they really? How many people actually believe in a knee jerk reaction to a problem? Sieglinde's distinction is important. Zeitgeist is a herd phenomena based on a multitude of beliefs of which not ONE is a valid bite of information to act on but we do. We twist and turn like a herd of wildebeest on the run. On the run from what? From those noisy helicopters hovering above, filming us, observing us, controlling us, steering us, compelling us. . .

    Don't let those helicopters make you feel any worse than you already do. Primal Pain is bad enough without all that hassle. . .

    Paul G.

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  6. For all who would like to know the truth:
    Nothing is more distressing to me than to feel something is wrong with my body and no doctor is willing or able to help, to look deeper or go beyond the pain-meds prescription pad.

    In 2012 I asked my biochemistry professor if he has upcoming lectures on gene methylation. Instead of answering, he asked why (he suspected my intention) and recommended a gene test. I did the test and since 2013 I know that I have over 600 markers and most of them related to IL (Interleukin). Inflammation (IL) is affecting organs, skin, vascular system (heart) the brain and hormone output. Inheriting bad genes is one subject, later gene methylation due to virus, bacteria, stress or neglect and/or abuse can be life-altering, because they make us sick.

    However it is not enough to know what genes are methylated, we need to know how to de-methylate, with Primal Therapy, snip out double helix or replace cancer genes, which must be the next science step.

    Now the University of Michigan has started “Genes for Good”, a free international gene testing program.
    Whoever likes to know the truth about damage inherited or later imprinted damage, instead of waiting for often incorrect diagnosis for the pain we endure daily, this link will lead you to a genetic eye-opener. http://genesforgood.sph.umich.edu/
    Sieglinde

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